The Latest: Israel and Iran trade fire in most serious confrontation since April truce

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Israel and Iran fired at each other on Monday while Yemen's Houthi rebels launched a missile at Israel and threatened to disrupt Red Sea shipping. It’s the most serious escalation since a ceasefire began two months ago and threatens to plunge the Middle East back into war.

Israeli authorities said three waves of Iranian missiles targeted the country. Explosions could be heard in central Israel as Israeli air defenses sought to intercept the incoming Iranian fire.

The Iranian attack came after Israel launched strikes on central and western Iran early Monday in response to missile fire from Tehran, in the most serious crossfire since an April 8 ceasefire was reached in the Iran war.

Tehran warned of retaliation after Israel struck Beirut’s southern suburbs on Sunday in defiance of Washington’s request days ago to stand down.

The Israeli strikes came in apparent defiance of President Donald Trump, who told Israeli Prime Minister Benjamin Netanyahu that he doesn’t think Israel needs to respond further.

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Lebanese Information Minister Paul Morcos released the toll Monday, two days after an Israeli airstrike on a vehicle in southern Lebanon killed three members of the Lebanese army, including a brigadier general and a captain.

Morcos said that since the Israel-Hezbollah war began on March 2, three police, one member of the General Security Directorate and 13 state security members have been killed in Israeli attacks. Also killed was a member of the parliament’s security.

A total of 3,613 people have been killed, according to the Lebanese Health Ministry.

The Israeli military has said it operates against Hezbollah and not against the Lebanese army.

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Damascus International Airport will remain closed until 11 p.m. (2200 GMT) Monday.

Syria’s General Authority of Civil Aviation closed the country’s southern airspace, which includes Damascus. The measure is related to the latest exchange of fire between Iran and Israel, it said.

Just before noon, air defense systems around Tehran and multiple Iranian cities opened fire, with some claims of attacks ongoing.

Oil prices surged as Israel launched airstrikes early Monday targeting central and western Iran in response to missile fire.

Brent crude, the international standard, jumped $4.40 to $97.49 a barrel. Benchmark U.S. crude surged $3.95 to $94.49 a barrel.

The latest spate of attacks was straining efforts to end the conflict as a tentative deal reached last week to extend a ceasefire between the U.S. and Iran has not yet been finalized.

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Israel’s military said it targeted truck-based surface-to-air missile launchers in its strikes Monday on Iran.

It said Iran had deployed the systems across the country in a bid to restore its capabilities that were degraded earlier in the war.

An Iranian official warned Monday that the United States is “responsible for the consequences of any escalation” in the Middle East caused by Israel.

Iranian Foreign Ministry spokesman Esmail Baghaei made the comment in a briefing with journalists on Monday in Tehran.

“No one believes that the Israeli regime would take any action without coordination with the United States,” Baghaei said. “The United States bears responsibility for the Israeli regime’s aggression, and it will also be responsible for the consequences of any escalation in tensions.”

Israel’s rescue services said there were not any known injuries from the latest round of missiles from Iran.

Rescue services are searching a number of sites for possible fragments from interceptions.

The Israeli military urged people to take shelter. Similar alerts sounded in neighboring Jordan.

The Iran-backed rebels also said that Israel-affiliated vessels would again be a target in the Red Sea.

The statement from Brig. Gen. Yahya Saree was broadcast on the Houthis’ al-Masirah satellite news channel.

It’s another new escalation as the nominal ceasefire in the Iran war is being challenged by crossfire between Israel and Iran.

Iran claimed the attacks on Israel, saying their fire targeted two military bases in Israel.

The paramilitary Revolutionary Guard described the attack as being part of Operation Nasr, or “Victory.” The Guard said it launched the missile fire after Israel targeted radar sites in three areas of Iran, without elaborating.

Israel’s military says it him a petrochemical complex in southwestern Iran. It did not provide details.

The semiofficial Fars and Mehr news agencies said Israeli strikes hit a petrochemical factory in city of Mahshahr in Khuzestan province. It did not elaborate on the damage done.

Israel issued an all-clear after warning of a second wave of inbound missiles from Iran.

It was the second alert without any interceptions being heard in the country.

The Iranian fire comes after Israel launched strikes on Iran early Monday in the most-serious crossfire since an April 8 ceasefire was reached in the Iran war.

Israel said it detected a barrage of missiles from Iran toward central and southern Israel on Monday morning. Loud explosions were heard over central Israel, and missiles also targeted southern Israel, near the city of Dimona and Arad.

The remote desert city of Dimona houses Israel’s main nuclear research center, which opened in 1958. Israel is widely believed to possess nuclear weapons, though its leaders neither confirm nor deny this.

Iran targeted Dimona and Arad during the last round of conflict, injuring more than two dozen people.

Israel’s rescue services said there were no reports of casualties or impacts from the launch from Yemen.

Israel’s military updated its guidelines for civilians on Sunday evening, limiting large gatherings and canceling school across the country.

It is the first time school has been canceled across Israel since the earlier round of fighting with Iran in April, though schools in Israel’s northern border had been closed for much longer due to the threat of Hezbollah fire.

Israel said Monday that it detected a missile launched from Yemen targeting the country. Sirens sounded across Israel after the Yemen missile fire warning.

Yemen is home to the Iranian-backed Houthi rebels. The Houthis have fired missiles at Israel during the Israel-Hamas war and later, but haven’t been fully involved in the Iran war.

Saudi Arabia sounded missile alert sirens Monday morning in an area home to an air base that hosts U.S. forces. Saudi state media reported the alert around its Al Kharj governorate, home to Prince Sultan Air Base.

It did not elaborate. The alert came after Israel launched strikes targeting Iran.

Speaking to The Financial Times, Trump before the Israeli strike on Iran insisted he dictated terms to Israeli Prime Minister Benjamin Netanyahu on how the war should be prosecuted.

“He won’t have any choice,” Trump told the newspaper in a telephone interview. “I call the shots. I call all the shots. He (Netanyahu) doesn’t call the shots.”

The White House did not respond to messages Sunday about the strikes and whether they were done in coordination with the U.S.

Iran closes airspace around Tehran’s Imam Khomeini International Airport, country’s main airfield, after Israeli attack.

Israel says it strikes central and Western Iran after missile fire; Tehran says explosions heard in several cities